Peptide News Digest

#2031-Loss-Of-Exclusivity

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Novo Nordisk Capital Markets Day in London Set for Monday September 21 as Week Ahead Centerpiece After Morgan Stanley Underweight Downgrade Cut Target to DKK 250 on Semaglutide Patent Cliff

Novo Nordisk (NYSE: NVO; Copenhagen: NOVO-B) heads into the week of September 14-19, 2026 with the September 21 Capital Markets Day in London one week away, and Friday September 11 fresh in investor minds. Morgan Stanley analyst Thibault Boutherin had cut Novo Nordisk to Underweight from Equal-weight Friday with a DKK 250 price target (implying more than 10% downside) citing subdued mid-term growth outlook plus concerns about the semaglutide loss-of-exclusivity beginning 2031 (semaglutide accounts for approximately 75% of Novo's 2026 sales). HSBC on Wednesday September 9 had raised its price target to DKK 320 (Hold), and Barclays on September 8 had trimmed its target to DKK 300 (Equal Weight). Novo shares closed the prior week down 2.8% in Copenhagen at DKK 278.2. The London Capital Markets Day is expected to unveil fresh strategic ambitions to replace existing targets, plus pipeline detail on CagriSema (cagrilintide + semaglutide) after the February 2026 Redefine-1 head-to-head miss versus Zepbound (23% vs 25.5% weight loss), amycretin (GLP-1/amylin unimolecular dual agonist Phase 3 planning), and the post-semaglutide non-GLP-1 diversification story after the September 7 HERMES + ATHENA ziltivekimab heart-failure trial terminations.

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Morgan Stanley Downgrades Novo Nordisk to Underweight Friday, Target Cut to DKK 250 on Semaglutide Patent Cliff Exposure; HSBC's Wednesday Move to DKK 320 Hold Frames the Analyst Split

Morgan Stanley analyst Thibault Boutherin and team cut Novo Nordisk (NYSE: NVO; Copenhagen: NOVO-B) to Underweight from Equal-weight on Friday September 11, 2026, with a DKK 250 price target implying more than 10% downside from current levels. The downgrade thesis: Novo's current valuation does not fully reflect the subdued mid-term growth outlook or the semaglutide patent-cliff implications on the company's terminal value. Semaglutide is expected to account for approximately 75% of Novo's 2026 sales; loss of exclusivity begins in 2031 across major markets. Morgan Stanley also flagged weaker momentum in U.S. Wegovy pill prescriptions following a stronger first half of 2026. Novo shares closed the week down 2.8% in Copenhagen at DKK 278.2 and 3.1% in Frankfurt at EUR 36.89. HSBC on Wednesday September 9 had raised its price target to DKK 320 (from DKK 300) while maintaining a Hold rating, framing the analyst split. Barclays cut its price target to DKK 300 from DKK 310 September 8 following the STEP Young + ziltivekimab HERMES/ATHENA split announcement, and Guggenheim earlier moved its target on Roivant/Pulmovant PHocus success. Novo executed DKK 9.02 billion of the DKK 15 billion share repurchase through September 4.