Peptide News Digest

#Acinetobacter-Baumannii

2 stories

Research · View digest

Anhui University Redesign of the MAP 34-B Peptide Kills E. coli and Acinetobacter baumannii Within Two Hours in Lab Tests

Researchers at Anhui University and a Guangdong marine science lab designed two derivatives of the antimicrobial peptide MAP 34-B. MAP 34B-1 was more active against E. coli and the drug-resistant hospital pathogen Acinetobacter baumannii, cut bacterial viability within two hours by disrupting membranes, kept working under the salt and heat conditions tested, and caused less damage to mammalian cells and red blood cells than MAP 34B-2, the Journal of Peptide Science paper reports. The work was done in cell cultures only.

Research · View digest

Nature Communications: Few-Shot AI Pipeline Designs Antimicrobial Peptides Against Carbapenem-Resistant Acinetobacter baumannii

A Nature Communications paper describes a deep-learning pipeline that uses pre-trained protein language models combined with few-shot fine-tuning to identify antimicrobial peptides effective against Acinetobacter baumannii, a WHO critical-priority pathogen. The classification, ranking, and regression modules collaboratively prioritize candidates with high predicted activity, expanding the chemical space accessible to data-poor AMR targets. Lead candidates showed potent in vitro activity against carbapenem-resistant clinical isolates.