Peptide News Digest

#Acquisitions

2 stories

Industry · View digest

argenx Agrees to Buy Unnatural Products for $550 Million Upfront and Up to $1.15 Billion to Add Macrocyclic Peptides

argenx will pay $550 million in cash upfront and up to $595 million in development and regulatory milestones for Santa Cruz, California-based Unnatural Products, whose discovery engine designs macrocyclic peptides, small ring-shaped chains of amino acids that can be built to bind disease targets. argenx said in its November 9 announcement that the peptides could support oral or long-acting medicines for immune-mediated diseases alongside its antibody work; the deal is expected to close by the end of 2026.

Industry · View digest

AstraZeneca Reportedly Offers About $10 Billion for Rhythm, Maker of the MC4R Peptide Drug Imcivree

AstraZeneca offered $124 a share, roughly $10 billion, for Rhythm Pharmaceuticals, The Wall Street Journal reported, citing people familiar with the matter, and Rhythm shares closed up 24% on November 4, BioSpace reported. Rhythm's setmelanotide (Imcivree), a peptide that activates the MC4R appetite receptor, won its third U.S. indication in March 2026 for acquired hypothalamic obesity and brought in $92.1 million in third-quarter sales. William Blair called Rhythm "a great strategic pickup for AstraZeneca."