Longhorn Vaccines' DRG5-BD11 Bispecific IgM Targets Bacterial Peptidoglycan at ESCMID 2026
Longhorn Vaccines and Diagnostics presents preclinical data on DRG5-BD11, a bispecific IgM monoclonal antibody targeting bacterial peptidoglycan and HSP16.3 across gram-positive, gram-negative, and mycobacterial pathogens. In vitro assays demonstrated 82% opsonophagocytic killing against E. coli and 74% against Mycobacterium smegmatis, supporting its potential as a broad-spectrum anti-infective for AMR-driven sepsis.