UT Health San Antonio Study of 72,521 GLP-1 Users Finds Higher Odds of Carpal and Cubital Tunnel Syndrome
In a retrospective TriNetX cohort matching 72,521 patients on GLP-1 receptor agonists with controls, GLP-1 users were more likely to be diagnosed with carpal tunnel syndrome (odds ratio 1.33) and cubital tunnel syndrome (OR 1.34), and those diagnosed were more likely to get steroid injections or surgery. Outcomes after nerve-release surgery did not differ, the paper in HAND reports. Diabetes and obesity are themselves risk factors for both conditions, and the authors say the mechanism is unclear.