University Hospital Basel Crossover Trial: Four Weeks of Dulaglutide Lowered Prolactin in 24 Healthy Young Men
In a secondary analysis of a randomized, double-blind, placebo-controlled crossover trial (NCT04687514), 24 healthy men with a median age of 24.5 took dulaglutide 1.5 mg weekly and placebo for four weeks each. Prolactin fell by 31.1 mU/L on dulaglutide and rose by 44.6 mU/L on placebo, and the 95% confidence interval for the estimated difference ran from −298.5 to −0.1 mU/L, just excluding zero. Prolactin levels were not associated with sexual desire, and the authors call for further study of GLP-1 drugs' hormonal effects.