Peptide News Digest

#Guidelines

4 stories

Regulatory · View digest

ADA Standards of Care in Diabetes 2026 Revised at Closing: Cardiovascular and Kidney Risk Reduction Elevated to Co-Primary Goal Alongside HbA1c

The ADA closed its 86th Scientific Sessions on June 8 with a formal revision to its Standards of Care that elevates cardiovascular and kidney risk reduction to a co-primary treatment goal alongside glycemic control, ending decades of practice in which HbA1c stood as the dominant benchmark. The shift formalizes a redefinition of diabetes care around the cardio-renal-metabolic axis that GLP-1, SGLT2, and finerenone evidence has driven, and pushes earlier GLP-1 and SGLT2 use from diabetes diagnosis.

Regulatory · View digest

ADA Releases Inaugural Standards of Care in Overweight and Obesity 2026: 34 New Recommendations, Pharmacologic Section, Five Percent Weight-Loss Target

On Saturday June 6, the Obesity Association (a division of the ADA) released the first stand-alone ADA Standards of Care in Overweight and Obesity: 34 new recommendations across seven sections, with a new pharmacologic-treatment section and a target of sustained body-weight reduction of at least 5%. The standards push obesity drugs from off-label discretion into anchored clinical-appropriateness criteria, the framework health systems and payers will use to write coverage policy.

Research · View digest

EASO Framework US Implementation Reception — Endocrinology Society Response Awaited as First-Line GLP-1 Algorithm Lands

The EASO 2026 Nature Medicine framework published May 14, presented at ECO 2026 — formally privileging semaglutide and tirzepatide as first-line therapy across most obesity complications with differentiated complication-specific recommendations — has generated initial reception coverage. The Endocrine Society and American Diabetes Association haven't yet issued formal endorsement or counter-response statements as of May 16, though informal commentary from US endocrinologists has been broadly favorable. The framework's main US-specific gap is its silence on cost and insurance access — the algorithm assumes prescribers can choose between semaglutide and tirzepatide based on clinical indication, but US patients without diabetes face the Medicare Part D weight-loss-only exclusion. The Medicare GLP-1 Bridge launching July 1, 2026 partly addresses that gap; broader integration awaits CMS rulemaking. ADA 2026 Scientific Sessions in New Orleans June 5-8 will be the next inflection point for guideline alignment between US and EASO positions.