Lundbeck's Vyepti Leaves 60% of Migraine Patients 'Much Improved' After a Prior CGRP Drug Fell Short, in Open-Label Phase 4 THRIVE Trial
Lundbeck reported headline results on Thursday, October 1, 2026 from THRIVE, an open-label Phase 4 trial of Vyepti (eptinezumab), an antibody against the neuropeptide CGRP, in 164 adults with at least eight monthly migraine days whose migraine had responded inadequately to one prior CGRP-targeting preventive, either a subcutaneous antibody or a gepant. Patients received 100 mg at baseline and 300 mg at week 12; at week 24, 60% rated themselves much or very much improved on the Patient Global Impression of Change scale, up from 44% at week 12, and 84% completed the study. There was no placebo group, and Lundbeck said no new safety signals were seen.