Peptide News Digest

#Maritime-Switch

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Amgen Presents at Morgan Stanley Global Healthcare Conference Tuesday With Jay Bradner (EVP R&D + AI) and Thomas Dittrich (CFO); MariTide Extended-Dosing Positioning Continues Following Last Week's Wells Fargo Conference

Amgen (NASDAQ: AMGN) presented Tuesday September 15, 2026 at 11:30 a.m. ET at the Morgan Stanley 24th Annual Global Healthcare Conference in New York with Jay Bradner MD (Executive Vice President Research and Development, Artificial Intelligence and Data) and Thomas Dittrich (Executive Vice President and CFO) — an unusual R&D-plus-finance pairing that indicates the AI-driven research investment thesis is a live investor question alongside the near-term MariTide (maridebart cafraglutide, antibody-peptide conjugate combining GLP-1 receptor agonism with GIP receptor antagonism) obesity narrative. The Wells Fargo Healthcare Conference presentation last Thursday September 10 laid out the MariTide dosing thesis (8-week or quarterly maintenance dosing, 4-6 doses per year after induction) plus the MARITIME-SWITCH Phase 3 conversion trial from weekly injectable semaglutide or tirzepatide onto monthly MariTide. Phase 2 data anchored 20% weight loss at 52 weeks plus reductions in triglycerides, hs-CRP, and an 11 mmHg blood pressure drop. Bradner is also expected to address the pipeline consolidation following the August discontinuation of AMG 513 (Phase 1 obesity), which left MariTide as the sole late-stage Amgen obesity asset. Filing is planned late 2026 to early 2027 with anticipated launch 2027-2028.

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Amgen Positions MariTide for 8-Week to Quarterly Maintenance Dosing (4-6 Doses per Year) at Wells Fargo Healthcare Conference; Phase 3 Long-Term Extension and Switch Studies Underway

Amgen (NASDAQ: AMGN) presented Thursday September 10, 2026 at the Wells Fargo 21st Annual Healthcare Conference in Boston, with Chief Medical Officer Paul Burton MD outlining a positioning for MariTide (maridebart cafraglutide, an antibody-peptide conjugate combining a GLP-1 receptor agonist peptide with a GIP receptor antagonist antibody scaffold) that could support 8-week or quarterly maintenance dosing (approximately 4-6 doses per year) after the induction phase. Phase 2 data showed about 20% weight loss at 52 weeks alongside lower triglycerides, lower high-sensitivity CRP, and an 11 mmHg drop in blood pressure. Two Phase 3 long-term extension studies (MARITIME-1 EXTENSION and MARITIME-2 EXTENSION) are examining lower maintenance dosing frequencies, plus a dedicated switch trial (MARITIME-SWITCH) testing conversion from weekly semaglutide or tirzepatide onto monthly MariTide. Six total Phase 3 MariTide trials enroll across obesity, obesity plus type 2 diabetes, obstructive sleep apnea, heart failure, and cardiovascular outcomes. Filing is planned late 2026 to early 2027 with anticipated launch 2027-2028. The 4% bone mineral density decline signal from Phase 1 remains a factor to watch in the Phase 3 dataset.