#Muscle-Mass

2 stories

Research April 18, 2026 · View digest

Omada Health: 12-Week GLP-1 Care Track Delivers 2.1x More Fat Loss While Preserving Muscle Mass

Omada Health published results from a 12-week study of 245 adults with obesity comparing its GLP-1 Care Track behavioral program (151 members) to a control group (94). Omada members lost 1.8x more total weight (6.0% vs 3.3% of starting weight), 2.1x more body fat, and saw increased muscle mass percentage and improved mental health scores. The finding directly addresses sarcopenia concerns highlighted in recent NPR coverage of GLP-1 discontinuation.

Research April 17, 2026 · View digest

Cell Reports Medicine: GLP-1 Weight Loss Does Not Cause Disproportionate Muscle Loss

A Cell Reports Medicine study presenting four preclinical experiments and a proof-of-concept clinical trial reports that GLP-1 medicines predominantly reduce body fat alongside a small but significant decrease in lean body mass in obese mice and humans. Among lean tissues, loss of liver mass exceeds change in muscle mass, and while absolute muscle mass and strength decrease, relative muscle mass and strength improve — translating into better running performance in mice.