Peptide News Digest

#Nature Communications

19 stories

Nature Communications publishes a steady stream of peptide-relevant primary research — typically mechanism work, structural biology, and AI-driven discovery papers that don't fit the broader Nature flagship. The journal is a regular source on this site for de novo peptide design, antimicrobial peptide work, peptide-drug conjugate chemistry, and structural studies on intracellular protein–protein interaction targets.

Representative pieces covered here: AI-discovered antimicrobial scaffolds, structural work on macrocyclic peptide binding to undruggable targets, bicyclic peptide chemistry from Bicycle Therapeutics and academic collaborators, and HLB Innovation's HMD-AMP transformer-based AMP discovery work.

Use this tag to scan the Nature Communications coverage. For broader Nature family work, see #nature-medicine for clinical and translational pieces.

Research · View digest

Nature Communications: Antimicrobial Peptide Transporter SbmA Structure Reveals ABC-Like Mechanism

A Nature Communications paper published April 15 reveals shared structural mechanisms between SbmA — an E. coli membrane transporter that imports antimicrobial peptides — and ABC transporters. Using cryo-electron microscopy, EPR spectroscopy, and molecular dynamics simulations, researchers demonstrated SbmA undergoes ABC-transporter-like conformational changes, informing strategies to design antibiotic-resistant-bacteria-penetrating peptide drugs.