#Peptide-Nanofibers

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Research October 31, 2026 · View digest

Sun Yat-sen University's Self-Assembling Peptide CQ7 Forms Nanofibers That Linger in the Lungs and Ease Fibrosis in Mice

Sun Yat-sen University researchers designed CQ7, a therapeutic peptide joined to a self-assembly motif so it forms nanofibers inside and outside cells, and reported in the Journal of Medicinal Chemistry that the fibers stayed in mouse lungs longer and improved delivery. Given by injection into the abdomen or by inhalation, CQ7 reduced fibrosis and inflammation in a mouse model of pulmonary fibrosis, and gene-expression work suggested it acts through mitochondrial function and oxidative stress. No human testing has been reported.

Research October 29, 2026 · View digest

Beijing Institute of Technology's PD-L1-Binding Peptide Fibers, Anchored in Microspheres, Stay in Tumors Longer and Pair With Ultrasound

The team picked EH, a β-sheet peptide that binds the immune checkpoint protein PD-L1, from an amphiphilic peptide library and grew it as aligned nanofibers inside the channels of PLGA microspheres loaded with immune-activating quantum dots. The design kept the peptide in tumors longer for sustained checkpoint blockade, and ultrasound-activated quantum dots set off immunogenic cell death. The authors report suppression of distant and metastatic tumors in animal tests.