Peptide News Digest

#Phase-2b

3 stories

Industry · View digest

Veru Inc. Presents Pre-Conference Workshop Session 'Moving Beyond BMI & Weight-Loss Endpoints to Advance the Regulatory Frontier & Redefine Clinical Success With the FDA' at the 4th Annual Obesity & Weight Loss Drug Development Summit in Boston on Tuesday July 14 at 1:30 PM ET, With CEO Mitchell Steiner Following on Wednesday July 15 With 'Combating Sarcopenic Obesity in Geriatrics by Combining GLP-1s With Selective Androgen Receptor Modulators (SARMs) to Prevent Muscle Loss' — Veru's Enobosarm-Plus-GLP-1 Program Anchors the Muscle-Preservation Thesis for Weight-Loss Therapy

Veru Inc. (NASDAQ: VERU), a late clinical-stage biopharmaceutical company focused on cardiometabolic and inflammatory diseases, presented at the 4th Annual Obesity & Weight Loss Drug Development Summit in Boston, Massachusetts on Tuesday July 14, 2026. Gary Barnette, PhD, Chief Scientific Officer, led the pre-conference workshop 'Moving Beyond BMI & Weight-Loss Endpoints to Advance the Regulatory Frontier & Redefine Clinical Success With the FDA' at 1:30 PM ET. On Wednesday July 15 at 4:20 PM ET, Chairman, President and CEO Mitchell Steiner, MD will present 'Combating Sarcopenic Obesity in Geriatrics by Combining GLP-1s With Selective Androgen Receptor Modulators (SARMs) to Prevent Muscle Loss.' Veru's lead asset enobosarm is a selective androgen receptor modulator (SARM) in Phase 2b development for muscle-loss prevention in older patients receiving GLP-1 receptor agonists for weight loss. The sarcopenic-obesity thesis directly addresses a widely documented GLP-1 side effect: approximately 25-40% of GLP-1-associated weight loss is lean muscle mass rather than fat, particularly in older patients. Veru's approach pairs the GLP-1 with a SARM to preserve muscle while maintaining fat loss.

Clinical Trials · View digest

Pfizer Berobenatide VESPER-1 Phase 2b at ADA 2026: 15.9% Weight Loss at 32 Weeks With No Plateau, Monthly Dosing Profile

Pfizer presented Phase 2b VESPER-1 data for berobenatide (PF-07976094 / PF'3944), the ultra-long-acting injectable GLP-1 peptide engineered for monthly dosing through a 0.5 mL low-volume injection. At ADA 2026, the 2.4 mg weekly dose drove up to 15.9% mean weight loss at 32 weeks with no plateau across the VESPER program, plus improved glycemic control and favorable tolerability. Pfizer plans more than 20 obesity-related trials in 2026, including 10 Phase 3 studies of berobenatide in chronic weight management, knee osteoarthritis, and obstructive sleep apnea. The asset entered Pfizer's pipeline through the $4.9 billion Metsera acquisition.

Clinical Trials · View digest

Liraglutide ELAD Phase 2b in Mild-to-Moderate Alzheimer's: Multicenter RCT Continues Driving GLP-1 Neurology Discussion

The ELAD trial — a multicenter, randomized, double-blind, placebo-controlled Phase 2b study of liraglutide in 204 mild-to-moderate Alzheimer's disease participants — published in Nature Medicine (online December 2025) continues to drive clinical-research discussions about GLP-1s in neurodegeneration. Coming after the Phase 3 EVOKE trials' negative cognition results, ELAD's intermediate-stage findings are being parsed for endpoints, mechanisms, and biomarker patterns that may guide future trial design in this contested indication.