University of Western Australia Trial: Resistance Training Cut Lean Mass Loss and Reversed Strength Loss on Tirzepatide
In a 40-week randomized trial of 120 adults with overweight or obesity, all taking tirzepatide (most reached 15 mg weekly), those assigned to thrice-weekly resistance exercise lost about the same weight as those who were not (22.3 vs. 22.6 kg) but less lean soft tissue mass (3.57 vs. 4.67 kg, difference 1.09 kg). Strength fell on tirzepatide alone (bench press down 4.09 kg) and rose with training (up 4.68 kg); adherence to the sessions was 91%, the Nature Medicine paper reports.