Peptide News Digest

#Syfovre

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Biogen (NASDAQ: BIIB) Reports Q2 2026 Earnings Before Market Open Wednesday July 29 With Revenue of $2.74 Billion (+3% Year-Over-Year), GAAP EPS $0.66, and Non-GAAP EPS $3.60 Beating Wall Street Consensus, Plus FDA Approval Announced for LEQEMBI IQLIK (Lecanemab-Irmb Subcutaneous Autoinjector) at-Home Initiation Dosing; The May 14, 2026 Apellis Acquisition Contributed $128 Million in Combined SYFOVRE (Pegcetacoplan Intravitreal) and EMPAVELI (Pegcetacoplan Subcutaneous) Partial-Quarter Revenue With Estimated Run-Rate Synergies of at Least $250 Million Exiting 2027

Biogen (NASDAQ: BIIB) reported Q2 2026 earnings before market open Wednesday July 29, 2026 with total revenue of $2.74 billion (+3% year-over-year), GAAP diluted EPS of $0.66, and non-GAAP diluted EPS of $3.60, beating Wall Street consensus. Growth-portfolio drugs (LEQEMBI, SKYCLARYS, SYFOVRE, and EMPAVELI) delivered year-over-year growth and, in aggregate, growth-portfolio revenue exceeded $1 billion for the quarter, surpassing Biogen's legacy multiple sclerosis franchise. Two major pipeline milestones anchored the earnings call: the FDA approved LEQEMBI IQLIK (lecanemab-irmb, a subcutaneous autoinjector formulation) for at-home initiation dosing (following the earlier approval of LEQEMBI IQLIK for maintenance dosing), providing patient-friendly dosing throughout the treatment course; and the Apellis acquisition that closed May 14, 2026 contributed $128 million in combined SYFOVRE (pegcetacoplan intravitreal, for geographic atrophy) and EMPAVELI (pegcetacoplan subcutaneous, for paroxysmal nocturnal hemoglobinuria and C3 glomerulopathy) revenue in the partial quarter. Biogen expects approximately 0.85 EPS dilution from the Apellis acquisition in 2026 with accretion in 2027 and estimated run-rate synergies of at least $250 million exiting 2027. 2026 revenue guidance raised to mid-single-digit growth with non-GAAP EPS guidance of $12-13.

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Biogen Completes $5.6B Apellis Pharmaceuticals Acquisition May 14, 2026 — Brings Cyclic Peptide Pegcetacoplan (EMPAVELI / SYFOVRE) With $689M 2025 Net Revenue Into the Growth Portfolio

Biogen (Nasdaq: BIIB) completed its $5.6B acquisition of Apellis Pharmaceuticals on May 14, 2026 after the May 13 tender offer closed at 82.4% of outstanding common stock at $41 per share in cash plus contingent value rights (up to $4 per share tied to SYFOVRE global net sales milestones). The transaction brings two commercialized peptide-based products into Biogen's portfolio: pegcetacoplan (EMPAVELI), a pegylated cyclic 13-amino-acid peptide complement C3 inhibitor approved for paroxysmal nocturnal hemoglobinuria (PNH) and C3 glomerulopathy / immune complex-membranoproliferative glomerulonephritis; and SYFOVRE, the intravitreal pegcetacoplan formulation for geographic atrophy secondary to age-related macular degeneration. Combined 2025 net product revenue was $689M. Biogen expects the deal to be Non-GAAP EPS accretive in 2027 and to materially increase Biogen's compound annual growth rate through end of decade. The deal restores a meaningful peptide-modality presence to Biogen's portfolio.