Henan Team Finds a 24-Amino-Acid Fragment of the Pig Antimicrobial Peptide PMAP-36 Blocks PRRS Virus Entry in Cells
Researchers at Henan Institute of Science and Technology screened porcine cathelicidin peptides against porcine reproductive and respiratory syndrome virus, which vaccines control poorly, and found that GI24, the first 24 amino acids of PMAP-36, blocked the virus from attaching to and entering cells. GI24 also reduced inflammatory signaling triggered by the virus and by bacterial endotoxin, working through the TREM1 gene, the Virology paper reports. The tests were done in cells only.