Peptide News Digest

Novo Nordisk + Anthropic Claude Deal, Zealand Metabolic Frontier 2030, Circle Pharma $92.5M Series E, Vera TRUTAKNA ORIGIN 3

Novo Nordisk-Anthropic Claude Science deal, Zealand Metabolic Frontier 2030, Circle Pharma $92.5M macrocycle Series E, Vera TRUTAKNA ORIGIN 3 results.

6 stories · Covering industry, clinical-trials

Editor's Note

Wednesday's news centered on Novo Nordisk and on commentary from the Morgan Stanley 24th Annual Global Healthcare Conference. Novo Nordisk announced a collaboration with Anthropic to test Claude Science in specific research and development workflows, and separately previewed 44 abstracts for EASD 2026 in Milan, including real-world Wegovy pill data from the OCTANE study. At the Morgan Stanley conference, Zealand Pharma CEO Adam Steensberg restated the company's Metabolic Frontier 2030 goal of five marketed products and 10 clinical programs by 2030, with petrelintide, its amylin analog partnered with Roche, at the center. Circle Pharma closed an oversubscribed $92.5 million Series E, with Eli Lilly among the investors, to take its oral macrocyclic cyclin D1 inhibitor CID-165 into the clinic in the first quarter of 2027. Vera Therapeutics reported that TRUTAKNA cut the risk of composite kidney disease progression by 76% over 104 weeks in the 428-patient ORIGIN 3 trial, and Diasome Pharmaceuticals named a new chief medical officer as it prepares HDV-Insulin for Phase 3.

Correction (September 23, 2026): This digest was revised to remove claims that could not be traced to a primary source and to replace general source links with specific ones. Corrected facts: the Roche–Zealand petrelintide agreement was announced in March 2025, not April 2026; Filspari (sparsentan) is not an Otsuka product, and that competitor reference was removed. A reference to a Roche Pharma Day on September 28, Phase 2b OPTI-2 hypoglycemia figures, and a comparison of the Novo–Anthropic deal to other pharma AI agreements were removed because the cited sources do not support them.

Novo Nordisk and Anthropic Announce Collaboration to Test Claude Science in Research and Development Workflows

Novo Nordisk and Anthropic announced on Wednesday, September 16, 2026 a collaboration under which Novo Nordisk will test Anthropic's Claude Science in specific research and development workflows and use Anthropic's frontier models for biological reasoning, drug discovery, and AI-driven software development. Financial terms were not disclosed. Novo Nordisk CEO Mike Doustdar said AI can help the company increase R&D productivity and "compress the path from research to marketed product." Anthropic co-founder and CEO Dario Amodei said giving researchers access to frontier models can shorten research timelines.

Novo Nordisk Previews 44 EASD 2026 Abstracts: Wegovy Pill Real-World OCTANE Data, CagriSema, and Zenagamtide for the September 28-October 2 Milan Meeting

Novo Nordisk said on Wednesday, September 16, 2026 that it will present 44 abstracts at the 62nd Annual Meeting of the European Association for the Study of Diabetes (EASD) in Milan, Italy, from September 28 to October 2. The OCTANE study will report real-world data on Wegovy pill use, including weight outcomes, treatment switching, and patient-reported outcomes. Other presentations cover Wegovy 7.2 mg; CagriSema (cagrilintide plus semaglutide) data on appetite regulation, eating behavior, body composition, and bone remodeling from the REDEFINE and REIMAGINE programs; and zenagamtide, the unimolecular GLP-1 and amylin receptor agonist formerly called amycretin.

Zealand Pharma Outlines Metabolic Frontier 2030 Goal of Five Marketed Products at Morgan Stanley Conference, Anchored on Petrelintide

Zealand Pharma CEO Adam Steensberg spoke on Wednesday, September 16, 2026 at the Morgan Stanley 24th Annual Global Healthcare Conference, where he described the company's Metabolic Frontier 2030 ambition, launched the previous December: five products on the market and 10 clinical programs by 2030. He said petrelintide, Zealand's long-acting amylin analog, produced double-digit weight loss with placebo-like tolerability in the Phase 2 ZUPREME-1 trial and is moving into Phase 3 with Roche. Under the agreement the companies announced on March 12, 2025, Roche paid $1.65 billion upfront, the deal's total potential value is up to $5.3 billion, and profits on petrelintide and the petrelintide/CT-388 combination are shared 50/50 in the U.S. and Europe. Steensberg also discussed survodutide, partnered with Boehringer Ingelheim, and glepaglutide for short bowel syndrome.

Circle Pharma Closes $92.5 Million Series E to Take Oral Macrocyclic Cyclin D1 Inhibitor CID-165 Into the Clinic for ER-Positive Breast Cancer

Circle Pharma announced on Wednesday, September 16, 2026 an oversubscribed $92.5 million Series E financing led by The Column Group, with participation from Nextech Invest, RA Capital Management, Euclidean Capital, and Eli Lilly and Company. The South San Francisco company said the money will take CID-165, which it describes as a first-in-class oral macrocyclic cyclin D1 RxL inhibitor, through early clinical development in ER-positive breast cancer and support its broader pipeline of cyclin-targeted macrocycles. Circle expects CID-165 to enter clinical development in the first quarter of 2027.

Vera Therapeutics' TRUTAKNA (Atacicept-Vymj) Cuts Composite Kidney Progression Risk 76% Over 104 Weeks in Phase 3 ORIGIN 3 Final Analysis in IgA Nephropathy

Vera Therapeutics reported on Tuesday, September 15, 2026 final efficacy results from the Phase 3 ORIGIN 3 trial of TRUTAKNA (atacicept-vymj) in 428 adults with primary IgA nephropathy at risk of progression. At 52 weeks, mean eGFR changed by -0.1 mL/min/1.73m² on TRUTAKNA versus -5.7 on placebo, and the annualized eGFR slope through 104 weeks was -0.6 versus -5.6 mL/min/1.73m² per year. TRUTAKNA cut the risk of composite kidney disease progression by 76% (hazard ratio 0.24; 11 versus 38 events), with no dialysis, transplant, or death events versus 8 on placebo, and proteinuria, galactose-deficient IgA1, and hematuria also fell significantly. Safety was generally comparable to placebo. Vera plans to submit a supplemental BLA for full approval in the fourth quarter of 2026 and reported more than 350 patient start forms in the first ten weeks of launch.

Diasome Pharmaceuticals Names Sangeeta Sawhney Chief Medical Officer and Expands Leadership as It Prepares HDV-Insulin for Phase 3

Diasome Pharmaceuticals announced on Tuesday, September 15, 2026 that it appointed Sangeeta Sawhney, M.D., as Chief Medical Officer as it prepares its lead program, HDV-Insulin, for Phase 3 development. Paul Strumph, M.D., who had been interim CMO, becomes senior medical advisor, and the company also named Linda Rubinstein chief financial officer, David Williams chief strategy officer, Karen Donovan head of commercial development, and David O'Reilly head of business development. Diasome says HDV-Insulin is designed to restore the liver's role in mealtime insulin action and improve the balance between glucose control and hypoglycemia risk. The announcement said the Phase 2b OPTI-2 trial had concluded but did not report its results or a Phase 3 timeline.