Bengaluru Case Report: Sodium Fell to 104 mmol/L 10 Days After a Woman Started Tirzepatide
A woman with type 2 diabetes and severe obesity who was also taking insulin and the diuretic torsemide developed loss of appetite, weakness, and drowsiness 10 days after starting tirzepatide, with a blood sodium of 104 mmol/L and lab results consistent with SIADH, a physician at Apollo Specialty Hospital in Bengaluru reported in the Indian Journal of Pharmacology. She improved with fluid restriction and hypertonic saline. A single case shows a timing association, not cause, and the author suggests checking electrolytes in patients with significant stomach symptoms or poor intake.