Peptide News Digest

#Subcutaneous-Conversion

2 stories

Industry · View digest

Halozyme Prices Upsized $1.3 Billion 1.50% Convertible Senior Notes Due 2033 Offering to Refinance 2027-2028 Maturities and Fund ENHANZE Recombinant Hyaluronidase (rHuPH20) Platform Expansion

Halozyme Therapeutics (NASDAQ: HALO) priced Thursday September 17, 2026 an upsized $1.3 billion aggregate principal amount of 1.50% convertible senior notes due 2033 — increased from the previously announced $1.05 billion offering size announced Wednesday September 16, 2026. Terms: 1.50% coupon, semi-annual interest, initial conversion rate of 7.1509 shares per $1,000 principal (approximately $139.84 per share initial conversion price). Halozyme will use approximately $652.5 million of proceeds to repurchase existing convertible notes maturing in 2027 and 2028; the balance funds general corporate purposes including working capital and potential acquisitions. Offering close targeted September 22, 2026. Halozyme is the innovator of the ENHANZE recombinant hyaluronidase drug-delivery technology (proprietary rHuPH20 enzyme), which enables subcutaneous conversion of intravenously administered biologics — deployed by 10+ marketed products across partners including Roche (Herceptin SC, Phesgo, Ocrevus Zunovo, Tecentriq Hybreza), J&J (Darzalex Faspro, Rybrevant SC), Bristol Myers Squibb (Opdivo Qvantig), argenx (Vyvgart Hytrulo), and Alteogen's competing ALT-B4 platform after Roche's separate September 8 Alteogen licensing deal.

Industry · View digest

Alteogen and Novartis Sign $3.2 Billion Option and License Agreement for ALT-B4 (Berahyaluronidase Alfa) Subcutaneous-Conversion Platform

Alteogen (KOSDAQ: 196170) announced Wednesday September 2, 2026 an option and license agreement with Novartis (NYSE: NVS) for the development and commercialization of subcutaneous formulations of multiple Novartis products using Alteogen's ALT-B4 (berahyaluronidase alfa) enabled by the proprietary Hybrozyme technology. Terms: up to $3.22 billion in aggregate potential value including option exercise fees, development and commercial milestone payments, plus royalties on net sales. ALT-B4 temporarily depolymerizes hyaluronan in the extracellular matrix, enabling co-administered biologics to disperse and absorb subcutaneously rather than requiring intravenous infusion. The transaction is Alteogen's fourth Hybrozyme deal in 2026 following prior agreements with Merck KGaA, Sanofi, and one undisclosed global pharma. The technology approach mirrors Halozyme Therapeutics's ENHANZE platform (used in Roche's SC Herceptin, Rituxan, and Ocrevus, plus Bristol Myers Squibb's SC Opdivo and Johnson & Johnson's SC Darzalex), and the SC-conversion category has become an anchor commercial strategy for pharma companies looking to extend patent life and improve patient convenience on established IV biologics.