PT-141 (Bremelanotide) Pricing: April 2026
PT-141 is unique: FDA-approved as Vyleesi ($0 with copay card, $99/box uninsured) and available compounded from $180/mo. Compounded forms include injection, nasal spray, and troches.
PT-141 (bremelanotide) is a melanocortin receptor agonist that works centrally in the brain to enhance sexual desire. It is unique among compounding peptides because it has an FDA-approved branded version — Vyleesi, approved in 2019 for hypoactive sexual desire disorder (HSDD) in premenopausal women.
Vyleesi is manufactured by Cosette Pharmaceuticals (acquired from Palatin Technologies in 2024) and dispensed exclusively through BlinkRx specialty pharmacy. The branded auto-injector lists at ~$930 per 4-dose box, but manufacturer programs bring the cost down dramatically: $0 with a commercial insurance copay card or $99/box for uninsured patients.
Meanwhile, compounded PT-141 is widely prescribed off-label — including for men with erectile dysfunction and low libido, which is not covered by the Vyleesi approval. Following the February 2026 HHS announcement, PT-141 compounding is now permitted under 503A and 503B pharmacy pathways. Compounded forms include injectable vials, nasal spray, sublingual troches, and combination tablets (e.g., bremelanotide + tadalafil). The standard dose is 1.75 mg subcutaneous, taken 45+ minutes before anticipated activity, with a maximum of 8 doses per month.
Vyleesi (FDA-Approved, Branded)
The branded PT-141 product, dispensed exclusively through BlinkRx specialty pharmacy. Available as a prefilled 1.75 mg auto-injector. Indicated for HSDD in premenopausal women.
| Channel | Price | Source |
|---|---|---|
| List Price (WAC) | ~$930/4-dose box | Drugs.com |
| Manufacturer Copay Card (Insured) | $0/box | Vyleesi.com |
| Uninsured Patient Program | $99/4-dose box | Vyleesi.com |
| Retail (No Insurance, No Program) | ~$290/dose | GoodRx |
| Discount Coupon (SaveHealth) | From $225.98/box | SaveHealth |
Compounded PT-141 (Rx Required)
Licensed compounding pharmacies offer PT-141 in multiple forms: injectable multi-dose vials, nasal spray, and sublingual troches. Prescribed off-label for both men and women. Requires a physician prescription.
| Channel | Price | Source |
|---|---|---|
| SweetSpot Labs (Nasal Spray) | $180 | SweetSpot Labs |
| HydraMed (Troches) | $220/30 troches | HydraMed |
| Wellcore (Injectable) | From $229 | Wellcore |
| Wellcore (Nasal Spray) | From $249 | Wellcore |
| APEX Medical (Injectable) | $250 | APEX Medical |
| HydraMed (Injectable Vial) | $299 | HydraMed |
| BeyondMD (Nasal Spray Program) | From $384 | BeyondMD |
Research Peptide Vendors (Research Use Only)
Sold strictly for in-vitro research purposes, not for human use. Lyophilized powder requiring reconstitution. Included for market context only.
| Channel | Price | Source |
|---|---|---|
| BioLongevity Labs (5mg) | ~$48/vial | BioLongevity Labs |
| SwissChems (10mg) | $49.99/vial | SwissChems |