Feinstein Institutes' Opsonic Peptide MOP3 Cuts Kidney Injury Markers After Blood-Flow Loss in Mice
Researchers at the Feinstein Institutes for Medical Research reported in Shock on October 13, 2026 that MOP3, a peptide derived from the protein MFG-E8 that tags the inflammatory signal eCIRP for removal by immune cells, reduced kidney damage when given as blood flow returned after 30 minutes of kidney ischemia in mice. Compared with untreated mice, MOP3 lowered circulating eCIRP by 40%, serum creatinine by 63%, blood urea nitrogen by 56%, and kidney injury markers such as KIM-1, and reduced tubular damage and cell death. The work is in mice.